In 2017, AmmoniaKnowHow.com and UreaKnowHow.com introduced global open source risk registers for ammonia and urea plants. On January 1, 2018, the Risk Register Safety Hazards in Urea Plants contained its first 100 safety hazards. This paper provides the detailed analysis of these hazards: In which plant sections and during which project phase do these safety hazards occur, which safety hazards occur most frequent, and which hazards have the highest risk factor. This paper describes the most critical safety hazards and recommends its prevention and mitigation measures. A surprising conclusion is that most safety hazards may lead to a sudden release of toxic ammonia. The paper provides suggestions on how to safely behave in a urea plant, and how to identify a maximum number of safety hazards.